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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 4888612
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mir3545
Name: microRNA 3545
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:16082926480464CTD9, 10-Dimethyl-1, 2-benzanthracene affects the expression of MIR203 mRNA

PMID:24792773
increases methylationISORGD:16082926480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased methylation of MIR203 promoter

PMID:24792773
multiple interactionsISORGD:16082926480464CTDButyric Acid inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene affects the expression of MIR203 mRNA], Butyric Acid inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased methylation of MIR203 promoter], Glucaric Acid inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene affects the expression of MIR203 mRNA], Glucaric Acid inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased methylation of MIR203 promoter], Niacinamide inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene affects the expression of MIR203 mRNA], Niacinamide inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased methylation of MIR203 promoter]

PMID:24792773
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.