GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:25550
Term: nitroaniline
Definition: A substituted aniline that carries one or more nitro groups.
Chemical ID: MESH:C008625
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDnitroaniline analog results in increased activity of CYP1A2 protein

PMID:9545601
increases expressionEXP 6480464CTDnitroaniline analog results in increased expression of CYP1A2 mRNA

nitroaniline analog results in increased expression of CYP1A2 protein

PMID:9545601
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.