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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:25858
Term: 1,7-dimethylxanthine
Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals.
Chemical ID: MESH:C021183
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7374686480464CTD1, 7-dimethylxanthine results in decreased expression of HSD11B2 mRNA

PMID:22701600
multiple interactionsISORGD:7374686480464CTD1, 7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein, ADORA2B mutant form inhibits the reaction [1, 7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein], ADORA2B mutant form inhibits the reaction [1, 7-dimethylxanthine results in decreased expression of HSD11B2 mRNA], Colforsin inhibits the reaction [1, 7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein], Colforsin inhibits the reaction [1, 7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]

PMID:22701600
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.