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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDReactive Oxygen Species results in increased expression of IL2 mRNA

PMID:22429591
multiple interactionsEXP 6480464CTD[6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of IL2 mRNA, [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of IL2 mRNA, [SOD2 protein results in decreased abundance of Reactive Oxygen Species] which results in decreased secretion of IL2 protein, SOD2 protein inhibits the reaction [Reactive Oxygen Species results in increased expression of IL2]

PMID:22429591
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.