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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 11250
Species: Mus musculus
CRRD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:27086
Term: tributylstannane
Definition: An organotin compound that has formula C12H28Sn.
Chemical ID: MESH:C011559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDtributyltin results in increased expression of RXRA mRNA

PMID:29787037, PMID:30027469
increases activityISORGD:7369296480464CTDtributyltin results in increased activity of RXRA protein

PMID:27131391
increases expressionISORGD:7369296480464CTDtributyltin results in increased expression of RXRA mRNA

PMID:29787037
multiple interactionsISORGD:7369296480464CTD[tributyltin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein, tributyltin inhibits the reaction [alitretinoin binds to RXRA protein], tributyltin inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]

PMID:15941851
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.