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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDCarbon Tetrachloride affects the expression of TIMP2 mRNA

PMID:15963342
increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of TIMP2 mRNA, Carbon Tetrachloride results in increased expression of TIMP2 protein

PMID:15860571, PMID:16033810, PMID:17094476, PMID:17156884, PMID:17631135, PMID:25150141
multiple interactionsEXP 6480464CTD2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA], [Carbon Tetrachloride co-treated with Celecoxib] results in increased expression of TIMP2 mRNA, obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]

PMID:15860571, PMID:16033810, PMID:16420518
affects expressionISORGD:621786480464CTDCarbon Tetrachloride affects the expression of TIMP2 mRNA

PMID:17484886
increases expressionISORGD:621786480464CTDCarbon Tetrachloride results in increased expression of TIMP2 mRNA, Carbon Tetrachloride results in increased expression of TIMP2 protein

PMID:14999682, PMID:15056808, PMID:16508911, PMID:16539848, PMID:18263696, PMID:20438794, PMID:25827057, PMID:29987408
multiple interactionsISORGD:621786480464CTD[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of TIMP2 mRNA, [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of TIMP2 protein, IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA], IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 protein], OSMR protein affects the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA], POMC protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]

PMID:14999682, PMID:16508911, PMID:16539848, PMID:25827057, PMID:29987408
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.