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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620196
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mmp13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCarbon Tetrachloride results in decreased expression of MMP13 mRNA

PMID:11903743, PMID:17485851
increases cleavageEXP 6480464CTDCarbon Tetrachloride results in increased cleavage of MMP13 protein

PMID:16484506
increases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of MMP13 mRNA, Carbon Tetrachloride results in increased expression of MMP13 protein

PMID:17631135, PMID:30723492, PMID:31150632
multiple interactionsEXP 6480464CTD[Aspirin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased cleavage of MMP13 protein, [Carbon Tetrachloride co-treated with Plant Extracts] results in increased expression of MMP13 mRNA, [Ibuprofen co-treated with Carbon Tetrachloride] results in increased expression of and results in increased cleavage of MMP13 protein, ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA], Pioglitazone affects the reaction [Carbon Tetrachloride results in increased cleavage of MMP13 protein], schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA]

PMID:11903743, PMID:16484506, PMID:17157831, PMID:21360558, PMID:31150632
affects expressionISORGD:15522436480464CTDCarbon Tetrachloride affects the expression of MMP13 mRNA

PMID:17484886
decreases expressionISORGD:15522436480464CTDCarbon Tetrachloride results in decreased expression of MMP13 mRNA

PMID:17976157
increases expressionISORGD:15522436480464CTDCarbon Tetrachloride results in increased expression of MMP13 mRNA, Carbon Tetrachloride results in increased expression of MMP13 protein

PMID:15056808, PMID:17187438, PMID:17944888, PMID:24639359, PMID:24802811, PMID:25827057, PMID:27042213, PMID:27339419
multiple interactionsISORGD:15522436480464CTD[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of MMP13 mRNA, [HAS3 protein affects the susceptibility to Carbon Tetrachloride] which affects the expression of MMP13 protein, acanthoic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein], HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA], HGF protein affects the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA], HIF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA], NT5E gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA], NT5E gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein], PLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein]

PMID:17944888, PMID:17976157, PMID:18263696, PMID:24639359, PMID:24802811, PMID:25827057, PMID:27042213
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.