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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:105116480464CTDCarbon Tetrachloride results in decreased expression of EGFR mRNA

PMID:29987408
increases expressionISORGD:105116480464CTDCarbon Tetrachloride results in increased expression of EGFR mRNA, Carbon Tetrachloride results in increased expression of EGFR protein

PMID:17484886, PMID:27477297
increases expressionISORGD:25436480464CTDCarbon Tetrachloride results in increased expression of EGFR mRNA

PMID:16644059, PMID:18006644
multiple interactionsISORGD:105116480464CTDNFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]], NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]], tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA], tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]

PMID:27477297
multiple interactionsISORGD:25436480464CTD[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased phosphorylation of EGFR protein, Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA], Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased phosphorylation of EGFR protein]

PMID:18006644, PMID:29923357
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.