GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70069
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cxcl2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7331186480464CTDCarbon Tetrachloride results in decreased expression of CXCL2 mRNA

PMID:17484886
increases expressionISOCRRD:7331186480464CTDCarbon Tetrachloride results in increased expression of CXCL2

Carbon Tetrachloride results in increased expression of CXCL2 mRNA

PMID:17125873, PMID:24639359, PMID:27339419, PMID:27865854, PMID:30056145
multiple interactionsISOCRRD:7331186480464CTDAnthocyanins inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2]

HIF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCL2 mRNA]

obeticholic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CXCL2 mRNA]

PMID:24639359, PMID:27865854, PMID:30056145
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.