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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1566319
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sesn2
Name: sestrin 2
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13468136480464CTD[Ethanol co-treated with Folic Acid] results in decreased expression of SESN2 mRNA, [Folic Acid deficiency co-treated with Methotrexate] results in increased expression of SESN2 mRNA

PMID:23378141, PMID:24657277
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.