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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:25436480464CTDDactinomycin inhibits the reaction [Estradiol results in increased expression of EGFR protein], Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of EGFR protein]

PMID:8888411
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.