GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects metabolic processingEXP 6480464CTDCYP1A2 protein affects the metabolism of Caffeine

PMID:15619608
increases activityEXP 6480464CTDCaffeine results in increased activity of CYP1A2 protein

PMID:15822860
multiple interactionsEXP 6480464CTD[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine

[N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine

Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]

CYP1A2 protein binds to and affects the metabolism of Caffeine

PMID:12706856, PMID:15659567, PMID:26599973
affects bindingISOCRRD:7357116480464CTDCYP1A2 protein binds to Caffeine

PMID:9334905
affects metabolic processingISOCRRD:7357116480464CTDCYP1A2 protein affects the metabolism of Caffeine

CYP1A2 protein affects the metabolism of Caffeine metabolite

PMID:1302044, PMID:14586384, PMID:14586387, PMID:15022032, PMID:15199075, PMID:15286053, PMID:15327588, PMID:15980104
decreases activityISOCRRD:104386480464CTDCaffeine results in decreased activity of CYP1A2 protein

PMID:18420780
decreases activityISOCRRD:7357116480464CTDCaffeine results in decreased activity of CYP1A2 protein

PMID:11465391, PMID:24211539
decreases methylationISOCRRD:104386480464CTDCYP1A2 protein results in decreased methylation of Caffeine

PMID:11376689
decreases methylationISOCRRD:7357116480464CTDCYP1A2 protein results in decreased methylation of Caffeine

PMID:11145498, PMID:12433797
increases metabolic processingISOCRRD:7357116480464CTDCYP1A2 protein results in increased metabolism of Caffeine

PMID:11907490, PMID:19215233, PMID:20716633
multiple interactionsISOCRRD:104386480464CTD[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA

PMID:28843594
multiple interactionsISOCRRD:7357116480464CTD[CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine

Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]

CYP1A2 protein binds to and affects the metabolism of Caffeine

GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]

resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]

rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]

PMID:11145498, PMID:11907490, PMID:15659567, PMID:15856409, PMID:16934051, PMID:19215233, PMID:20716633
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.