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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730973
Species: Mus musculus
CRRD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding factor 2
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13077516480464CTDCaffeine results in increased expression of SREBF2 mRNA, Caffeine results in increased expression of SREBF2 protein

PMID:30825513
increases expressionISORGD:7309726480464CTDCaffeine results in increased expression of SREBF2 mRNA, Caffeine results in increased expression of SREBF2 protein

PMID:30825513
multiple interactionsISORGD:7309726480464CTD2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA], Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA], Resveratrol inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]

PMID:30825513
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.