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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3728
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Snap25
Name: synaptosome associated protein 25
Acc ID: CHEBI:27808
Term: heroin
Definition: A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.
Chemical ID: MESH:D003932
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7341516480464CTDHeroin results in decreased expression of SNAP25 mRNA

PMID:16710320
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.