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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1312683
Species: Homo sapiens
CRRD Object: Gene
Symbol: EZH2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDresveratrol results in increased expression of EZH2 mRNA, resveratrol results in increased expression of EZH2 protein

PMID:26934322
increases response to substanceEXP 6480464CTDEZH2 mRNA results in increased susceptibility to resveratrol

PMID:26934322
multiple interactionsEXP 6480464CTD[Coumestrol co-treated with resveratrol] results in increased expression of EZH2 mRNA, EZH2 mRNA promotes the reaction [resveratrol results in decreased expression of ACTA2 mRNA], EZH2 mRNA promotes the reaction [resveratrol results in decreased expression of ZEB1 mRNA]

PMID:19167446, PMID:26934322
decreases expressionISORGD:13126846480464CTDresveratrol results in decreased expression of EZH2 protein

PMID:25505154
multiple interactionsISORGD:13126846480464CTDMIR137 mRNA affects the reaction [resveratrol results in decreased expression of EZH2 protein]

PMID:25505154
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.