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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1566319
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sesn2
Name: sestrin 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13468136480464CTDresveratrol results in decreased expression of SESN2 mRNA

PMID:19167446
increases expressionISORGD:13468136480464CTDresveratrol results in increased expression of SESN2 mRNA, resveratrol results in increased expression of SESN2 protein

PMID:23651738, PMID:25533949
multiple interactionsISORGD:13468136480464CTDPARP1 protein affects the reaction [resveratrol results in increased expression of SESN2 protein], STF-118804 inhibits the reaction [resveratrol results in increased expression of SESN2 protein]

PMID:25533949
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.