RGD Gene Chemical Interaction Report - Chinchilla Research Resource Database

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID:	1316368
Species:	Homo sapiens
CRRD Object:	Gene
Symbol:	ZEB2
Name:	zinc finger E-box binding homeobox 2

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of ZEB2 mRNA	PMID:27392435, PMID:27594783
multiple interactions	EXP		6480464	CTD	Cisplatin promotes the reaction [jinfukang results in decreased expression of ZEB2 mRNA], jinfukang promotes the reaction [Cisplatin results in decreased expression of ZEB2 mRNA]	PMID:27392435

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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