GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2325580
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mir99a
Name: microRNA 99a
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCisplatin results in increased expression of MIR99A mRNA

PMID:24880025
decreases response to substanceISOCRRD:13498086480464CTDMIR99A mRNA results in decreased susceptibility to Cisplatin

PMID:27994509
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.