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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3704
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc2a1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7372726480464CTDCisplatin results in decreased expression of SLC2A1 mRNA

PMID:29690507
increases expressionISOCRRD:7372726480464CTDCisplatin results in increased expression of SLC2A1 mRNA

PMID:25596134
increases phosphorylationISOCRRD:113056480464CTDCisplatin results in increased phosphorylation of SLC2A1 protein

PMID:22006019
multiple interactionsISOCRRD:7372726480464CTD[Cisplatin co-treated with 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one] promotes the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA]

[Cisplatin co-treated with jinfukang] results in increased expression of SLC2A1 mRNA

Oxygen deficiency inhibits the reaction [Cisplatin results in decreased expression of SLC2A1 mRNA]

PMID:27392435, PMID:29690507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.