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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619838
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pabpc1
Name: poly(A) binding protein, cytoplasmic 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13498486480464CTDCisplatin results in decreased expression of PABPC1 mRNA

PMID:27594783
decreases expressionISORGD:15524486480464CTDCisplatin results in decreased expression of PABPC1 protein

PMID:29733421
increases response to substanceISORGD:13498486480464CTDPABPC1 protein results in increased susceptibility to Cisplatin

PMID:21466612
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.