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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620732
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ephx2
Name: epoxide hydrolase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7310556480464CTDCisplatin results in decreased expression of EPHX2 mRNA, Cisplatin results in decreased expression of EPHX2 protein

PMID:26165641
increases expressionISORGD:7310546480464CTDCisplatin results in increased expression of EPHX2 mRNA

PMID:27392435
multiple interactionsISORGD:7310546480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of EPHX2 mRNA

PMID:27392435
multiple interactionsISORGD:7310556480464CTDEdaravone inhibits the reaction [Cisplatin results in decreased expression of EPHX2 protein]

PMID:26165641
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.