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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621821
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Fen1
Name: flap structure-specific endonuclease 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:7326796480464CTDFEN1 protein affects the susceptibility to Cisplatin

PMID:16217747
decreases expressionISORGD:7326806480464CTDCisplatin results in decreased expression of FEN1 mRNA

PMID:21151649
increases expressionISORGD:7326796480464CTDCisplatin results in increased expression of FEN1 mRNA

PMID:27594783
multiple interactionsISORGD:7326796480464CTDCisplatin inhibits the reaction [Piroxicam results in decreased expression of FEN1 mRNA]

PMID:21858171
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.