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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 731251
Species: Mus musculus
CRRD Object: Gene
Symbol: Syt13
Name: synaptotagmin XIII
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Syt13decreases phosphorylationEXP 6480464CTDCisplatin results in decreased phosphorylation of SYT13 protein

PMID:22006019
Syt13affects expressionISORGD:7352436480464CTDCisplatin affects the expression of SYT13 mRNA

PMID:23300844
Syt13multiple interactionsISORGD:7352436480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of SYT13 mRNA

PMID:27392435
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.