GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620196
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mmp13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:27902
Term: tetracycline
Definition: A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
Chemical ID: MESH:D013752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:13432676480464CTDTetracycline analog results in decreased activity of MMP13 protein

PMID:17267227
multiple interactionsISOCRRD:13432676480464CTDTetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]

Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]

PMID:17267227
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.