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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619837
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Neo1
Name: neogenin 1
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7334256480464CTD[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of NEO1 protein, Cocaine promotes the reaction [DRD1 protein results in increased expression of NEO1 protein], Cocaine promotes the reaction [DRD3 protein results in decreased expression of NEO1 protein]

PMID:15056714
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.