GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2710
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Glul
Name: glutamate-ammonia ligase
Acc ID: CHEBI:28001
Term: vancomycin
Definition: A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.
Chemical ID: MESH:D014640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDVancomycin results in increased expression of GLUL mRNA

PMID:18289764
increases expressionISOCRRD:7361816480464CTDVancomycin results in increased expression of GLUL mRNA

PMID:18930951
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.