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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70946
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pip
Name: prolactin induced protein
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13513256480464CTDGenistein results in decreased expression of PIP protein

PMID:20884965
increases expressionISORGD:13513256480464CTDGenistein results in increased expression of PIP protein

PMID:20884965
multiple interactionsISORGD:13513256480464CTDESR1 promotes the reaction [Genistein results in decreased expression of PIP protein], ESR2 promotes the reaction [Genistein results in increased expression of PIP protein]

PMID:20884965
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.