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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1303325
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nelfe
Name: negative elongation factor complex member E
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationEXP 6480464CTDTetrachlorodibenzodioxin results in increased phosphorylation of NELFE protein

PMID:23298284
affects expressionISORGD:16215696480464CTDTetrachlorodibenzodioxin affects the expression of NELFE mRNA

PMID:21570461
decreases expressionISORGD:16215696480464CTDTetrachlorodibenzodioxin results in decreased expression of NELFE mRNA

PMID:21354282
multiple interactionsISORGD:16215696480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NELFE mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NELFE promoter]

PMID:17942748, PMID:19654925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.