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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1307026
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Slc39a14
Name: solute carrier family 39 member 14
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13159766480464CTDTetrachlorodibenzodioxin affects the expression of SLC39A14 mRNA

PMID:21570461
decreases expressionISORGD:13159766480464CTDTetrachlorodibenzodioxin results in decreased expression of SLC39A14 mRNA

PMID:26290441, PMID:28213091
multiple interactionsISORGD:13159766480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SLC39A14 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SLC39A14 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SLC39A14 gene]

PMID:16214954, PMID:25975270, PMID:28213091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.