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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1315070
Species: Mus musculus
CRRD Object: Gene
Symbol: Samd8
Name: sterile alpha motif domain containing 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SAMD8 mRNA

PMID:28213091
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SAMD8 mRNA

PMID:19465110, PMID:24680724
multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SAMD8 gene]

PMID:28213091
increases expressionISORGD:13064476480464CTDTetrachlorodibenzodioxin results in increased expression of SAMD8 mRNA

PMID:21215274
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.