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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1563633
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Edem1
Name: ER degradation enhancing alpha-mannosidase like protein 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of EDEM1 mRNA

PMID:22298810
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of EDEM1 mRNA

PMID:21215274
affects expressionISORGD:15578136480464CTDTetrachlorodibenzodioxin affects the expression of EDEM1 mRNA

PMID:21570461
multiple interactionsISORGD:15578136480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of EDEM1 mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EDEM1 mRNA

PMID:16214954, PMID:17942748
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.