GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1591402
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Phldb2
Name: pleckstrin homology-like domain, family B, member 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:15582496480464CTDTetrachlorodibenzodioxin results in decreased expression of PHLDB2 mRNA

PMID:19770486
increases expressionISOCRRD:13506766480464CTDTetrachlorodibenzodioxin results in increased expression of PHLDB2 mRNA

PMID:20106945, PMID:21632981
multiple interactionsISOCRRD:15582496480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PHLDB2 mRNA

PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.