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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1593189
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gsta5
Name: glutathione S-transferase alpha 5
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of GSTA5 mRNA

PMID:16054898, PMID:21215274, PMID:21496263
affects expressionISORGD:16201186480464CTDTetrachlorodibenzodioxin affects the expression of GSTA1 mRNA

PMID:18343893, PMID:26377647
increases activityISORGD:16201186480464CTDTetrachlorodibenzodioxin results in increased activity of GSTA1 protein

PMID:16243960
increases expressionISORGD:13446236480464CTDTetrachlorodibenzodioxin results in increased expression of GSTA5 mRNA

PMID:21496263
increases expressionISORGD:16201186480464CTDTetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA, Tetrachlorodibenzodioxin results in increased expression of GSTA1 protein, Tetrachlorodibenzodioxin results in increased expression of GSTA5 mRNA

PMID:16243960, PMID:18372398, PMID:19474220, PMID:21496263, PMID:22496397, PMID:22579925, PMID:22611038, PMID:28213091
multiple interactionsISORGD:16201186480464CTDAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], ammonium metavanadate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], ammonium metavanadate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]], Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], Copper promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein], Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein], Lead promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein], Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein], Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], Mercury promotes the reaction and results in increased expression of Tetrachlorodibenzodioxin promotes the reaction and results in increased expression of GSTA1 mRNA, NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein], sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GSTA1 gene], Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein

PMID:16243960, PMID:19474220, PMID:22496397, PMID:22535251, PMID:22579925, PMID:22611038, PMID:28213091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.