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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 619742
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cdh11
Name: cadherin 11
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:13517736480464CTDTetrachlorodibenzodioxin results in decreased expression of CDH11 mRNA

PMID:19619570, PMID:19901195
decreases expressionISOCRRD:15529786480464CTDTetrachlorodibenzodioxin results in decreased expression of CDH11 mRNA

PMID:24035824
multiple interactionsISOCRRD:13517736480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDH11 mRNA

PMID:19619570
multiple interactionsISOCRRD:15529786480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CDH11 promoter]

PMID:19654925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.