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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620403
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ccs
Name: copper chaperone for superoxide dismutase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7336076480464CTDTetrachlorodibenzodioxin affects the expression of CCS mRNA

PMID:20702594, PMID:21570461
increases expressionISORGD:7336076480464CTDTetrachlorodibenzodioxin results in increased expression of CCS mRNA

PMID:18796159, PMID:19770486
multiple interactionsISORGD:7336076480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of CCS mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of CCS mRNA

PMID:16214954, PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.