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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA

PMID:19520675
affects expressionISORGD:7332946480464CTDTetrachlorodibenzodioxin affects the expression of APAF1 mRNA

PMID:21570461
decreases expressionISORGD:7332936480464CTDTetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA

PMID:19684285
decreases expressionISORGD:7332946480464CTDTetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA

PMID:23864506
multiple interactionsISORGD:7332936480464CTD[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNA

PMID:19684285
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.