GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 631435
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Orc1
Name: origin recognition complex, subunit 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISOCRRD:13321826480464CTDTetrachlorodibenzodioxin affects the expression of ORC1 mRNA

PMID:16962184
affects expressionISOCRRD:13504066480464CTDTetrachlorodibenzodioxin affects the expression of ORC1 mRNA

PMID:22574217
multiple interactionsISOCRRD:13504066480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of ORC1 mRNA

PMID:26159488
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.