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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 67378
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ncam1
Name: neural cell adhesion molecule 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of NCAM1 mRNA

PMID:21602191
affects expressionISORGD:7369886480464CTDTetrachlorodibenzodioxin affects the expression of NCAM1 mRNA

PMID:16962184
decreases expressionISORGD:7369886480464CTDTetrachlorodibenzodioxin results in decreased expression of NCAM1 mRNA

PMID:19465110
increases expressionISORGD:7369886480464CTDTetrachlorodibenzodioxin results in increased expression of NCAM1 mRNA

PMID:21167638
multiple interactionsISORGD:7369886480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NCAM1 promoter]

PMID:19654925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.