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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69224
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gpx3
Name: glutathione peroxidase 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of GPX3 mRNA

PMID:20959002
affects expressionISORGD:13438586480464CTDTetrachlorodibenzodioxin affects the expression of GPX3 mRNA

PMID:22298810
increases activityISORGD:7373826480464CTDTetrachlorodibenzodioxin results in increased activity of GPX3 protein

PMID:16682824
increases expressionISORGD:13438586480464CTDTetrachlorodibenzodioxin results in increased expression of GPX3 mRNA

PMID:19692669, PMID:21296121
increases expressionISORGD:7373826480464CTDTetrachlorodibenzodioxin results in increased expression of GPX3 mRNA, Tetrachlorodibenzodioxin results in increased expression of GPX3 protein

PMID:16682824, PMID:17035482, PMID:21041162
increases response to substanceISORGD:7373826480464CTDGPX3 protein results in increased susceptibility to Tetrachlorodibenzodioxin

PMID:16682824
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.