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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 735521
Species: Homo sapiens
CRRD Object: Gene
Symbol: NEDD8
Name: NEDD8 ubiquitin like modifier
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:109686480464CTDTetrachlorodibenzodioxin results in decreased expression of NEDD8 mRNA

PMID:19770486
increases expressionISORGD:31586480464CTDTetrachlorodibenzodioxin results in increased expression of NEDD8 mRNA

PMID:18796159
multiple interactionsISORGD:109686480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD8 mRNA

PMID:17942748
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.