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CRRD ID: 737411
Species: Homo sapiens
CRRD Object: Gene
Symbol: AQP8
Name: aquaporin 8
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7374126480464CTDTetrachlorodibenzodioxin affects the expression of AQP8 mRNA

PMID:21570461, PMID:26377647
decreases expressionISORGD:7374126480464CTDTetrachlorodibenzodioxin results in decreased expression of AQP8 mRNA

PMID:28213091, PMID:28922406
multiple interactionsISORGD:7374126480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AQP8 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of AQP8 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AQP8 gene]

PMID:17942748, PMID:25975270, PMID:28213091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.