Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2866
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:28148
Term: sodium stibogluconate
Definition: A D-gluconate adduct of indefinite composition containing between 30 and 34% of antimony(V), calculated with reference to dried and methanol-free substance. It is used as a treatment for leishmaniasis.
Chemical ID: MESH:D000967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngaffects response to substanceISORGD:7374886480464CTDIFNG protein affects the susceptibility to Antimony Sodium Gluconate

PMID:10603400
Ifngdecreases expressionISORGD:7374876480464CTDAntimony Sodium Gluconate results in decreased expression of IFNG mRNA

PMID:20102417, PMID:9498473
Ifngmultiple interactionsISORGD:7374876480464CTD[Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG protein

PMID:17911647
Ifngmultiple interactionsISORGD:7374886480464CTD[IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL10 mRNA, [IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL4 mRNA, [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of IL12B mRNA, [IFNG protein co-treated with Antimony Sodium Gluconate] results in increased expression of NOS2 mRNA, IFNG protein affects the reaction [IL10RA protein affects the susceptibility to Antimony Sodium Gluconate]

PMID:12870129, PMID:9234779
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.