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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2886
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:28148
Term: sodium stibogluconate
Definition: A D-gluconate adduct of indefinite composition containing between 30 and 34% of antimony(V), calculated with reference to dried and methanol-free substance. It is used as a treatment for leishmaniasis.
Chemical ID: MESH:D000967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10affects response to substanceISORGD:107856480464CTDIL10 protein affects the susceptibility to Antimony Sodium Gluconate

PMID:12379707
Il10decreases expressionISORGD:7355916480464CTDAntimony Sodium Gluconate results in decreased expression of IL10 mRNA

PMID:20102417, PMID:9498473
Il10multiple interactionsISORGD:107856480464CTD[IFNG protein co-treated with Antimony Sodium Gluconate] results in decreased expression of IL10 mRNA

PMID:9234779
Il10multiple interactionsISORGD:7355916480464CTD[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of IL10 protein

PMID:17911647
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.