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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1344166
Species: Homo sapiens
CRRD Object: Gene
Symbol: OPA1
Name: OPA1 mitochondrial dynamin like GTPase
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDRotenone results in increased expression of OPA1 protein

PMID:21223980
decreases expressionISORGD:7084236480464CTDRotenone results in decreased expression of OPA1 mRNA, Rotenone results in decreased expression of OPA1 protein

PMID:26770656
increases expressionISORGD:7084236480464CTDRotenone results in increased expression of OPA1 mRNA

PMID:19013527
multiple interactionsISORGD:7084236480464CTDresveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 mRNA], resveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 protein], resveratrol promotes the reaction [Rotenone results in decreased expression of OPA1 mRNA]

PMID:26770656
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.