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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2707
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gls
Name: glutaminase
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDmethylmercuric chloride results in increased activity of GLS protein

PMID:22223486
multiple interactionsEXP 6480464CTDPolyphenols inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein]

PMID:22223486
decreases expressionISOCRRD:7366366480464CTDmethylmercuric chloride results in decreased expression of GLS mRNA

PMID:23179753
increases expressionISOCRRD:7366366480464CTDmethylmercuric chloride results in increased expression of GLS mRNA

PMID:28001369
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.