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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2860
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Id3
Name: inhibitor of DNA binding 3, HLH protein
Acc ID: CHEBI:28445
Term: vincristine
Definition: A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Chemical ID: MESH:D014750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases response to substanceISORGD:7340696480464CTDID3 gene SNP results in increased susceptibility to Vincristine

PMID:21245421
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.