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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1605705
Species: Homo sapiens
CRRD Object: Gene
Symbol: GREB1
Name: growth regulating estrogen receptor binding 1
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDkaempferol results in increased expression of GREB1 mRNA

PMID:20846786
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA], kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer], kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]

PMID:20846786
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.