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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730927
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Vitamin E co-treated with Quercetin co-treated with kaempferol co-treated with 3, 4-dihydroxyphenylethanol] results in decreased expression of IL5 mRNA, kaempferol inhibits the reaction [Calcimycin results in increased expression of IL5 mRNA]

PMID:12789233, PMID:16797527
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.