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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 736871
Species: Homo sapiens
CRRD Object: Gene
Symbol: DHFR
Name: dihydrofolate reductase
Acc ID: CHEBI:28680
Term: cytarabine
Definition: A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties.
Chemical ID: MESH:D003561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCytarabine results in increased expression of DHFR mRNA

PMID:19194470
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