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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1305382
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ube2c
Name: ubiquitin-conjugating enzyme E2C
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13133786480464CTDDoxorubicin results in decreased expression of UBE2C mRNA, Doxorubicin results in decreased expression of UBE2C protein

PMID:27129209, PMID:29803840
multiple interactionsISORGD:13133786480464CTD[Doxorubicin results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein, TP53 protein inhibits the reaction [Doxorubicin results in decreased expression of UBE2C protein]

PMID:27129209
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.